Assignment of the human gene for endosarcomeric cytoskeletal M-protein (MYOM2) to 8p23.3.

Results: The FISH results place DACH and Dach within well-characterized region of extensive homology between uman chromosome 13 and mouse chromosome 14 (Fig. 1). his region covers the distal portion of mouse chromosome 14 rom 41 to 70 cM (the telomere) and two-thirds of the long rm of human chromosome 13 from 13q14–q32 (data taken rom the human/mouse homology map, http://www.ncbi.nlmnih.gov/Homology/ and the Mouse Chromosome 14 Commitee Report, http://www.informatics.jax.org/bin/ccr/index). On he integrated map of human chromosome 13, the DACH TS WI-5860 lies just distal of EDNRB, which is one of the arkers included in the comparative map (Fig. 1). Therefore t is likely that mouse Dach maps close to Ednrb, which is ocated at 51 cM on mouse chromosome 14. Additional comments: Two disease loci of interest have een mapped to 13q: RIEG2 (Rieger syndrome type 2, OMIM 01499) and PAP-A2 (postaxial polydactyly type A2, OMIM 02085). DACH lies outside the critical interval for RIEG2, ut is located at the proximal extreme of the critical interval or PAP-A2 (near D13S800). Given the expression pattern of ouse Dach in the developing limb (3), DACH could be a andidate for PAP-A2.